The Arf tumor suppressor acts as a sensor of oncogenic signals. countering aberrant proliferation in large part via activation of the p53 transcriptional program. though a number of p53-independent functions have been described. Mounting evidence suggests that. https://www.darthomes.shop/product-category/napkin-rings/
Loss of p19(Arf) facilitates the angiogenic switch and tumor initiation in a multi-stage cancer model via p53-dependent and independent mechanisms.
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